![]() ![]() The blend was then granulated with binding agent, which was prepared. Salbutamol and magnesium oxide (light) were passed through 40# mesh and mixed homogenously using polybag. Slurry of agar was prepared by allowing it to swell completely in 100 ml of warm water by stirring continuously using mechanical stirrer for 2 h. Pre-formulation studies had shown that agar used in dry powder form is not much effective as release retarding agent and more amounts is required to get the same effect as lesser amount of slurry is used. Tablets were prepared by wet granulation technique using agar and gelatin in combination and these polymers were used as binder in the form of aqueous homogenous slurry. Salbutamol was a generous gift from Department of Pharmaceutics, Jamia Hamdard University, New Delhi. Gelatin used in the pharmaceutical industries is a blend of these two types, although sometimes only Type A or Type B is used. GELATIN VS AGAR AGAR SKINType B gelatin (pH 5.0–7.4 isoelectric point 4.7–5.3) is derived by basic hydrolysis of bones and animal skin and contributes high gel strength to the blend. ![]() Type A gelatin (pH 3.8–6.0 isoelectric point 6–8) is derived by acidic hydrolysis of pork skin and contributes plasticity and elasticity to the blend. The two types of gelatins are characterized by their mode of manufacture. Gelatin type A (from porcine skin, bloom number 175) and type B (from bovine skin, bloom number 225) gelatin were purchased from Sigma-Aldrich and used as received. It has been extracted from the red seaweed Gracilaria dura collected from the Gulf of Mannar at the southeast coast of India, employing a patented method. Herein, the effect of various agar-gelatin compositions on the release of salbutamol is discussed.Īgar was a gift from Central Salt and Marine Research Institute, Bhavnagar, Gujrat. Though inhaled therapy is ideal for treatment of asthma as drug is directed directly to lungs thus increasing the efficacy of drug and also has minimal side effects but for very young, old and handicapped patients, unable to use inhaler, oral administration of drug is better alternative. It is well absorbed following oral administration with peak plasma level occurring within 14 h ( T max). ![]() Here, we reported preparation of agar-gelatin blend tablets of salbutamol, a selective β 2 adrenoreceptor agonists, widely used for treatment of asthma which leads to the relaxation of bronchial smooth muscle and inhibits hyper sensitivity of mast cells. Polymer blending give improved physical and mechanical properties due to their synergistic effect and thus are good candidates for controlled drug delivery systems. Agar is being used as sustained release agent in tablets, gels beads, microspheres and topical formulations, as swelling agent, viscosity increasing agent in aqueous systems and as suspending agent in pharmaceutical suspensions but work on agar-gelatin blends tablets are scarce. These include proteins (gelatin), polysaccharides (chitosan, agar, acacia, agarose) and gummy exudates (guar gum, gum karaya). Varieties of natural polymers are being used effectively in various pharmaceutical products. Controlled or sustained release is advantageous as they provide desired activity and maintain desired therapeutic level of drug for prolonged period of time and reduce the number of doses, thus are emerging as better alternative over conventional immediate release medication. Polymer matrices are promising candidates in drug release controlling agents and are widely used in various dosage forms in pharmaceutical industry. The better controlling behavior of polymer blends was explained by specific interaction between polymer components, their network structure and polymer–drug interaction. Polymer blends were more effective in controlling drug release. Polymer compositions were fixed based on our desired sustaining activity of the tablet which showed a biphasic release profile with immediate release followed by sustained release. Dissolution profiles of tablets were compared among the tablets made of agar, gelatin A, gelatin B and their blends agar-gelatin A, agar-gelatin B, gelatin A-gelatin B and agar-gelatin A-gelatin B in 1:1 ratio. GELATIN VS AGAR AGAR FREEFormulations were optimized based on their invitro release performed in enzyme free simulated gastric fluid (0.1 N HCl, pH 1.2). Pre-formulation trials were initiated by comprising different ratios of polymer blend in the tablets. The purpose is to observe the role of polymer composition on the modified dissolution rate of salbutamol. The study was designed for the development of salbutamol-modified release tablet using various polymer composition of agar, gelatin A and gelatin B. ![]()
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